They alter the way it cleaves amyloid precursor protein 它們改變了這個(gè)酶切割淀粉樣蛋白前體的方式。
Application of thrombus precursor protein in patients with cardiovascular disease 血栓前體蛋白在心血管疾病中的應(yīng)用
Amyloid plaques form when a molecule called amyloid precursor protein ( app ) is chopped up by two enzymes known as beta - secretase and gamma - secretase 當(dāng)一種叫淀粉樣前體蛋白( app )的分子被兩種酶? ?分別叫作貝塔-分泌酶和伽瑪-分泌酶? ?切斷時(shí)就形成了淀粉樣斑塊。
In this process , protein translocation machineries of the outer and inner membranes , at least three major translocase complexes , are needed to ensure the proper import of precursor proteins 在此過程中,需要線粒體外膜和內(nèi)膜的蛋白質(zhì)運(yùn)輸機(jī)器(至少三種主要的移位酶復(fù)合物)來保證前體蛋白質(zhì)的正確運(yùn)輸。
Carville dg , dirmtrijevic n , walsh m , et al . thrombus precursor protein : marker of thrombosis early in the pathogenesis of myocardial infarction [ j ] . clin chem , 1996 , 42 ( 9 ) : 1537 諸俊,何曉東,葉書來,等.急性心肌梗死與不穩(wěn)定心絞痛患者血栓前體蛋白和肌酸激酶的檢測[ j ] .中國動(dòng)脈硬化雜志, 2002 , 10 ( 2 ) : 165 - 166
The cdna contains 947 nucleotides that codes for a precursor protein of 216 amino acids . sequence analysis shows that the n - terminal 1 - 25 amino acid sequence is a predicted signal peptide and other 26 - 216 amino acid sequence is a mature peptide which has no transmembrane domain Ecbp21cdna全長947bp ,編碼216個(gè)氨基酸,序列分析顯示其n端1 - 25氨基酸為信號(hào)肽, 26 - 216氨基酸為成熟蛋白肽段,并且不具有跨膜結(jié)構(gòu)域。
This peptide is derived from proteolytic processing of the amyloid precursor protein ( app ) . an increasing ' amount of experiments show that a p can induce various toxic reaction in brain , thus play a causal role in the pathogenesis of alzheimer ' s disease ( ad ) . in the meantime , the incapability of neurons to regenerate in ad patients means that it may inhibit the proliferation , differentiation and even survival of nscs 3 .體外培養(yǎng)14天后,取部分細(xì)胞,加入不含bfgf僅含egf ( 20n留ml )的無血清培養(yǎng)基,分為三組:對(duì)照組; ap25一35毒性組加入20umol /的凝聚態(tài)a目25一35 :雌激素保護(hù)組同時(shí)加入zoumolz的凝聚態(tài)ap25一35和10一7mo比17一p雌二醇。